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The Madness Men aren't fighting a conventional evil today. But the similarities to their regular enemies are certainly there. They are just faceless devils trying to take you down. For a price, of course. And the more villains and mercenaries you cut down under a hail of bullets, the more money you'll make until your guns are all out of ammo.
There's no real explanation for why anything happens. And that's especially true of the madness series.
Use the Arrow keys to run.
Press the Spacebar to jump.
Use the mouse to aim and fire.